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11/15/2008 05:00 AM

Higher dose vaccine could be more effective

By: Casey Bortnick

Higher dose vaccine could be more effective
Older adults and people with chronic diseases are at the greatest risk of problems associated with the flu. Because older adults have reduced cough and gag reflexes, they often have increased respiratory problems associated with flu.

For senior citizens who already have Chronic Obstructive Pulmonary Disease, or other respiratory problems, a flu shot is even more important.

"Even so much as the common cold could put me in the hospital," said Sally Linton. “So probably the flu could put me in the cemetery," she added.

Linton has trouble breathing and needs an oxygen tank. She tries to avoid getting sick.

"If my grandchildren have the flu bug or something, I try not to be huggy and kissy and that kind of thing. But I also don't stay home and hibernate," Linton said.

Linton protects herself with a standard vaccine.

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"I believe in a flu shot for anyone that’s old enough to get it," Linton added.

Since those over the age of 65 at the highest risk for complications from the flu, researchers at two Rochester area hospitals tried to come up with a more potent defense.

"The current flu vaccine is effective but it's not nearly as good as it can be particularly in older people," said Infectious Disease Specialist Dr. Ann Falsey.

As part of a study, at the University of Rochester and Rochester General Hospital, seniors were given a vaccine dose four times larger than normal.

"And the people who received the high dose vaccine had a significantly higher antibody response than those who got the standard vaccine," Falsey said.

Antibodies are the body's natural defense. The more you have the better your chances of fighting off the flu.

"It sounds very simplistic but more is better. How much better is the question," Falsey said.

Falsey presented her findings to the Infectious Disease Society of America. The data may be encouraging but some are still cautious.

"So whether getting a stronger shot would make any difference, I don't know," said Linton.

For now, Linton says the standard vaccine works just fine.

“In the past yes, hopefully it will be again this year," Linton added.

To see the study go to
eurekalert.org.